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Background Info

• Age group: 9–10 years old (n = 574)
• Cohort: GDM-exposed (gestational diabetes mellitus) children
• Measure used for ordering: Cortical thickness deviations from healthy controls (HCs)
  • i.e., SuStaIn is modeling abnormal thinning trajectories compared to HC norms.
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1. Lobe-level Developmental Ordering

• Subtype 1 ( n = 372, 65%): insula → occipital_lobe → parietal_lobe → temporal_lobe → frontal_lobe → cingulate
• Subtype 2 ( n = 202, 35%): frontal_lobe → parietal_lobe → temporal_lobe → occipital_lobe → cingulate → insula

HC ( n = 3557): occipital_lobe → parietal_lobe → frontal_lobe → temporal_lobe → insula → cingulate

2. Baseline Profiling (between subtypes)

No significant difference

1. Demographic characteristics, age, sex, race, puberty stage, household income
2. Pregnancy-related features, birth weight, maternal age, gestational age, alcohol and/or tobacco use
3. Behavioral measures, CBCL
4. Cognitive measures, NIH toolbox

More details of the comparisons, please refer to,

Longitudinal-Analysis-1008.html

Significant difference

1. Anthropometric measures, BMI*, weight*, height*, waist*
2. Neuroimaging measures, rs-fMRI(ns after adjustment), MRI ( cortical)